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Lancet. 2000 Jan 1;355(9197):39-40.

Hypocretin (orexin) deficiency in human narcolepsy.

Abstract

Alterations in the hypocretin receptor 2 and preprohypocretin genes produce narcolepsy in animal models. Hypocretin was undetectable in seven out of nine people with narcolepsy, indicating abnormal hypocretin transmission.

PMID:
10615891
DOI:
10.1016/S0140-6736(99)05582-8
[Indexed for MEDLINE]

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