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Nat Med. 2000 Jan;6(1):29-34.

Transplantation of male germ line stem cells restores fertility in infertile mice.

Author information

1
Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3850 Baltimore Ave., Philadelphia, Pennsylvania 19104, USA.

Abstract

Azoospermia or oligozoospermia due to disruption of spermatogenesis are common causes of human male infertility. We used the technique of spermatogonial transplantation in two infertile mouse strains, Steel (Sl) and dominant white spotting (W), to determine if stem cells from an infertile male were capable of generating spermatogenesis. Transplantation of germ cells from infertile Sl/Sld mutant male mice to infertile W/Wv or Wv/W54 mutant male mice restored fertility to the recipient mice. Thus, transplantation of spermatogonial stem cells from an infertile donor to a permissive testicular environment can restore fertility and result in progeny with the genetic makeup of the infertile donor male.

PMID:
10613820
PMCID:
PMC4879876
DOI:
10.1038/71496
[Indexed for MEDLINE]
Free PMC Article
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