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J Membr Biol. 2000 Jan 1;173(1):1-8.

NAADP: An emerging calcium signaling molecule.

Author information

1
Department of Pharmacology, 6-120 Jackson Hall, 321 Church St. SE, University of Minnesota, Minneapolis, MN 55455, USA.

Abstract

Cells possess multiple Ca(2+) stores and multiple messengers for mobilizing them. In addition to inositol trisphosphate and cyclic ADP-ribose, nicotinic acid adenine dinucleotide phosphate (NAADP), a metabolite of NADP, is shown to be a potent Ca(2+) signaling molecule in both invertebrate and mammalian cells. This article summarizes the recent results of this newly discovered Ca(2+) signaling mechanism and explores the implications of the apparent proliferation of Ca(2+) messengers.

PMID:
10612686
DOI:
10.1007/s002320001001
[Indexed for MEDLINE]

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