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Trends Cell Biol. 1999 Dec;9(12):M5-8.

Lateral genomics.

Author information

1
Canadian Institute for Advanced Research, Dept of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada. ford@is.dal.ca

Abstract

More than 20 complete prokaryotic genome sequences are now publicly available, each by itself an unparalleled resource for understanding organismal biology. Collectively, these data are even more powerful: they could force a dramatic reworking of the framework in which we understand biological evolution. It is possible that a single universal phylogenetic tree is not the best way to depict relationships between all living and extinct species. Instead a web- or net-like pattern, reflecting the importance of horizontal or lateral gene transfer between lineages of organisms, might provide a more appropriate visual metaphor. Here, I ask whether this way of thinking is really justified, and explore its implications.

PMID:
10611671
[Indexed for MEDLINE]

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