Format

Send to

Choose Destination
See comment in PubMed Commons below
Ann Intern Med. 1999 Dec 7;131(11):834-7.

Chlorhexidine compared with povidone-iodine as skin preparation before blood culture. A randomized, controlled trial.

Author information

1
Université Paris XI, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.

Abstract

BACKGROUND:

Chlorhexidine is better than povidone-iodine for care of catheter sites, but it is not known whether chlorhexidine is superior in reducing blood culture contamination.

OBJECTIVE:

To determine whether alcoholic chlorhexidine is a more effective skin antiseptic for collection of blood cultures than aqueous povidone-iodine.

DESIGN:

Randomized, controlled trial.

SETTING:

Three adult intensive care units in a French university hospital.

PATIENTS:

403 adults who had at least one blood culture drawn through a peripheral vein.

INTERVENTIONS:

Patients were randomly assigned to receive skin preparation with an aqueous solution of 10% povidone-iodine or an alcoholic solution of 0.5% chlorhexidine before phlebotomy.

MEASUREMENTS:

Contamination rates of blood cultures.

RESULTS:

Of 2041 blood cultures collected in 403 patients, 124 yielded pathogens. Chlorhexidine reduced the incidence of blood culture contamination more than povidone-iodine (14 of 1019 cultures [1.4%] compared with 34 of 1022 cultures [3.3%]; odds ratio, 0.40 [95% CI, 0.21 to 0.75]; P = 0.004).

CONCLUSION:

Skin preparation with alcoholic chlorhexidine is more efficacious than skin preparation with aqueous povidone-iodine in reducing contamination of blood cultures.

PMID:
10610628
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center