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Kidney Int. 1999 Oct;56(4):1223-9.

Oxidant-induced apoptosis of glomerular cells: intracellular signaling and its intervention by bioflavinoid.

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Department of Medicine, University College London Medical School, England, United Kingdom.


Oxidant stress plays a crucial role in the generation of a wide range of glomerular disease. In the first part of this article, we describe intracellular signaling pathways involved in the oxidant-initiated apoptosis of mesangial cells, especially highlighting the tyrosine kinase-c-Jun/AP-1 pathway. In the second part, we address a novel potential of bioflavonoid quercetin as an inhibitor of apoptosis in glomerular cells. Possible mechanisms for the antiapoptotic action of quercetin and its therapeutic utility are discussed.

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