The role of RXR-alpha in retinoic acid-induced cleft palate as assessed with the RXR-alpha knockout mouse

Int J Dev Biol. 1999 Sep;43(6):567-70.

Abstract

Treatment of pregnant mice with retinoic acid (RA) in mid-gestation produces cleft palate and limb defects in the fetuses. RXR-alpha has been previously shown to mediate the teratogenic effects of RA in the limb. In this study, we show that RXR-alpha is also involved in retinoid-induced palatal clefting. Treatment of RXR-alpha knockout mice with a teratogenic dose of RA on gestation day 11 or 12 induces cleft palate at a lower frequency than that seen in wild-type animals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cleft Palate / chemically induced*
  • Cleft Palate / metabolism
  • Fetus / abnormalities
  • Fetus / metabolism
  • Mice
  • Mice, Inbred ICR
  • Mice, Knockout
  • Receptors, Retinoic Acid / metabolism*
  • Retinoid X Receptors
  • Teratogens / toxicity*
  • Transcription Factors / metabolism*
  • Tretinoin / toxicity*

Substances

  • Receptors, Retinoic Acid
  • Retinoid X Receptors
  • Teratogens
  • Transcription Factors
  • Tretinoin