Abstract
Treatment of pregnant mice with retinoic acid (RA) in mid-gestation produces cleft palate and limb defects in the fetuses. RXR-alpha has been previously shown to mediate the teratogenic effects of RA in the limb. In this study, we show that RXR-alpha is also involved in retinoid-induced palatal clefting. Treatment of RXR-alpha knockout mice with a teratogenic dose of RA on gestation day 11 or 12 induces cleft palate at a lower frequency than that seen in wild-type animals.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cleft Palate / chemically induced*
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Cleft Palate / metabolism
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Fetus / abnormalities
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Fetus / metabolism
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Mice
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Mice, Inbred ICR
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Mice, Knockout
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Receptors, Retinoic Acid / metabolism*
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Retinoid X Receptors
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Teratogens / toxicity*
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Transcription Factors / metabolism*
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Tretinoin / toxicity*
Substances
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Receptors, Retinoic Acid
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Retinoid X Receptors
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Teratogens
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Transcription Factors
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Tretinoin