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J Infect Dis. 2000 Jan;181(1):2-9.

Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity.

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1
Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. david.vaughn@na.amedd.army.mil

Abstract

Viremia titers in serial plasma samples from 168 children with acute dengue virus infection who were enrolled in a prospective study at 2 hospitals in Thailand were examined to determine the role of virus load in the pathogenesis of dengue hemorrhagic fever (DHF). The infecting virus serotype was identified for 165 patients (DEN-1, 46 patients; DEN-2, 47 patients; DEN-3, 47 patients, DEN-4, 25 patients). Patients with DEN-2 infections experienced more severe disease than those infected with other serotypes. Eighty-one percent of patients experienced a secondary dengue virus infection that was associated with more severe disease. Viremia titers were determined for 41 DEN-1 and 46 DEN-2 patients. Higher peak titers were associated with increased disease severity for the 31 patients with a peak titer identified (mean titer of 107.6 for those with dengue fever vs. 108.5 for patients with DHF, P=.01). Increased dengue disease severity correlated with high viremia titer, secondary dengue virus infection, and DEN-2 virus type.

PMID:
10608744
DOI:
10.1086/315215
[Indexed for MEDLINE]
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