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Curr Opin Struct Biol. 1999 Dec;9(6):722-31.

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes.

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Department of Chemistry, The Oxford Centre for Molecular Sciences, The Dyson Perrins Laboratory, Oxford, OX1 3QY, UK.


Mononuclear nonheme-Fe(II)-dependent oxygenases comprise an extended family of oxidising enzymes, of which the 2-oxoglutarate-dependent oxygenases and related enzymes are the largest known subgroup. Recent crystallographic and mechanistic studies have helped to define the overall fold of the 2-oxoglutarate-dependent enzymes and have led to the identification of coordination chemistry closely related to that of other nonheme-Fe(II)-dependent oxygenases, suggesting related mechanisms for dioxygen activation that involve iron-mediated electron transfer.

[Indexed for MEDLINE]

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