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Curr Opin Genet Dev. 1999 Dec;9(6):709-14.

The minimal genome concept.

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1
Akkadix Corporation, La Jolla 92037, USA. mushegian@akkadix.com

Abstract

Complete genome sequences are becoming available for a large number of diverse species. Quantification of gene content, of gene family expansion, of orthologous gene conservation, as well as their displacement, are now possible - laying the ground for the estimation of the minimal set of proteins sufficient for cellular life. The consensus of computational results suggests a set close to 300 genes. These predictions will be evaluated by engineering of small bacterial genomes.

PMID:
10607608
[Indexed for MEDLINE]
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