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J Am Acad Dermatol. 2000 Jan;42(1 Pt 1):25-32.

Improvement of early recognition of lentigo maligna using dermatoscopy.

Author information

1
Department of Dermatology, University of Regensburg, and Dermatology Associates, Tallahassee.

Abstract

BACKGROUND:

The clinical differentiation between lentigo senilis/initial seborrheic keratosis and lentigo maligna on the face can be difficult.

OBJECTIVE:

Our purpose was to determine whether dermatoscopy (eg, skin surface microscopy at 10x magnification) can reliably differentiate between these entities.

METHODS:

Dermatoscopic slides of 87 consecutive patients presenting 37 malignant and 50 benign pigmented skin lesions on the face were analyzed with the use of 27 dermatoscopic criteria.

RESULTS:

Univariate analysis selected two criteria specific for lentigo maligna: asymmetric pigmented follicular openings and dark (brown or black) rhomboidal structures. Location-specific importance in relation to facial location was attributed to the color "slate-gray, " especially in combination with structures such as dots, globules, streaks, and homogeneous areas. Multivariate analysis (logistic regression model) revealed the 4 most important features to be asymmetric pigmented follicular openings, dark rhomboidal structures, slate-gray globules, and slate-gray dots with a sensitivity of 89% and a specificity of 96%.

CONCLUSION:

Three conclusions can be drawn from our study: With a set of 4 dermatoscopic features, early lentigo maligna can be detected with high accuracy; dermatoscopic features on the face differ from criteria used in other locations; and our progression growth model for lentigo maligna delineates the different steps of malignant growth in lentigo maligna.

PMID:
10607316
[Indexed for MEDLINE]

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