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FEBS Lett. 1999 Dec 17;463(3):301-6.

Cloning, functional characterisation and population analysis of a variant form of the human glycine type 2 transporter.

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  • 1Molecular Biology Department, SmithKline Beecham Pharmaceuticals, Harlow, UK.


Two forms of glycine transporter have been described to date, GlyT-1 and GlyT-2. The GlyT-2 form is expressed mainly in the spinal cord, brainstem and cerebellum. Here we describe the identification of a variant form of the human GlyT-2 (SC6), showing three amino acid changes to the previously reported protein. Population analysis identified the allele causing one of the polymorphisms, D463N, at 10% within the population with 3% being homozygous for the change. We also transfected our new variant into mammalian cells and compared it to the published cDNA, showing that the three amino acid changes present have no major effect on the biochemical properties of the transporter.

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