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Epilepsy Res. 2000 Jan;38(1):27-32.

Gabapentin in childhood epilepsy: a prospective evaluation of efficacy and safety.

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1
Kinderklinik Kidron, Epilepsiezentrum Bethel, Bielefeld, Germnany. kme@neuro.mara.de

Abstract

PURPOSE:

To evaluate the efficacy and safety of gabapentin (GBP) in partial epilepsy in children.

METHODS:

We performed a prospective open label add-on study in 52 children and adolescents (age 1.8-17.5 years, mean 11.1 years) with refractory partial seizures. Gabapentin was added to one other baseline drug and the efficacy was rated according to seizure type and frequency.

RESULTS:

The GBP dose ranged from 26 to 78 mg/kg per day (mean 52 mg/kg per day) and was well tolerated in most patients. The seizure frequency remained unchanged in 34 patients (65%). We saw a provocation of seizures in three children (6%). Initially 15 patients (29%) benefited from GBP: five (10%) with a seizure reduction of 50-74%, seven (13%) with a reduction of 75-99% and three (6%) became seizure free. All but three experienced a development of tolerance within the next weeks to months.

CONCLUSIONS:

Although gabapentin seems also to be safe in children, the efficacy in refractory partial seizures was disappointing.

PMID:
10604603
[Indexed for MEDLINE]
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