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Proc Nutr Soc. 1999 Aug;58(3):609-13.

A genetic dissection of the retinoid signalling pathway in the mouse.

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Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, C.U. de Strasbourg, France.


To determine the functions of retinoic acid receptors RAR and RXR, we have systematically knocked-out their genes by homologous recombination in the embryonic stem cells and generated null-mutant mice. This approach has allowed us to perform a genetic dissection of the retinoic acid signalling pathway.

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