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Microbes Infect. 1999 May;1(6):437-43.

The pathogenesis of Acanthamoeba keratitis.

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Southwestern Medical School, 5323 Harry Hines Blvd, Dallas, Texas 75235-9057, USA.


Free-living amoebae of the genus Acanthamoeba produce a progressive, blinding infection of the corneal surface. The pathogenesis of Acanthamoeba keratitis involves parasite-mediated cytolysis and phagocytosis of corneal epithelial cells and induction of programmed cell death. Acanthamoeba spp. elaborate a variety of proteases which may facilitate cytolysis of the corneal epithelium, invasion of the extracellular matrix, and dissolution of the corneal stromal matrix.

[Indexed for MEDLINE]

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