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Curr Opin Chem Biol. 1999 Dec;3(6):659-64.

Selectin-carbohydrate interactions in shear flow.

Author information

1
Department of Biomedical Engineering, University of Virginia, Health Sciences Center, Box 377, Charlottesville, VA 22908, USA. mbl2a@virginia.edu.

Abstract

Hydrodynamic shear creates mechanical stresses on selectin bonds, modulating affinity and kinetic parameters. Chemical modification of sialyl Lewis(x) increases the strength of L-selectin bonds without altering recognition, suggesting that mechanical and biorecognition characteristics are separable. L-selectin bond formation rates may be strongly influenced by sulfate orientation in sulfo sialyl Lewis(x).

PMID:
10600725
DOI:
10.1016/s1367-5931(99)00023-x
[Indexed for MEDLINE]

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