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Curr Opin Biotechnol. 1999 Dec;10(6):557-63.

Nuclear receptor regulation of cholesterol and bile acid metabolism.

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Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235-9050, USA.


The metabolism of cholesterol and bile acids is transcriptionally regulated by classic feedforward and feedback signaling pathways. The mechanisms underlying this regulation have recently been elucidated by the characterization of three classes of orphan nuclear receptors. Furthermore, the study of these receptors suggests their potential as targets for new drug therapies.

[Indexed for MEDLINE]

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