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Virchows Arch. 1999 Aug;435(2):79-86.

The Epstein-Barr virus: a group 1 carcinogen?

Author information

1
Pathologisches Institut, Friedrich-Alexander-Universit├Ąt, Erlangen. gerald.niedobitek@patho.med.uni-erlangen.de

Abstract

The Epstein-Barr virus (EBV) is a human herpes virus with the ability to transform B-lymphocytes in vitro. EBV has been linked to the pathogenesis of a variety of human tumours, including Burkitt's lymphoma, immunosuppression-related lymphomas, Hodgkin's disease, nasal angiocentric T/NK-cell lymphoma and nasopharyngeal carcinoma. Based on the association of the virus with these tumours, EBV has been classified as a group 1 carcinogen by the WHO International Agency for Research on Cancer. In this article, the evidence suggesting that EBV is carcinogenic to humans is briefly reviewed.

PMID:
10599304
DOI:
10.1007/s004280050402
[Indexed for MEDLINE]

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