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Semin Cell Dev Biol. 1999 Oct;10(5):523-30.

Gene duplications in early metazoan evolution.

Author information

1
Department of Medical Biochemistry and Microbiology, BMC, Uppsala, Sweden. lg.lundin@medkem.uu.se

Abstract

Major increases in complexity during animal evolution occurred at the transition from a unicellular protozoan to a multicellular metazoan, the evolution of Bilateria from diploblasts (possibly the Cambrian explosion) and during early vertebrate evolution. A role for gene duplication in the third event has been widely discussed. Here I examine the possible role of gene duplications and domain shuffling in the first two events. There is evidence for a wave of gene duplications and shuffling which may have paved the way for multicellularity; there are also examples of gene duplications that may have facilitated the transition from diploblasts to Bilateria.

PMID:
10597636
DOI:
10.1006/scdb.1999.0333
[Indexed for MEDLINE]

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