Send to

Choose Destination
See comment in PubMed Commons below
Genet Epidemiol. 1999;17 Suppl 1:S79-83.

Cleaning genotype data.

Author information

Marshfield Medical Research Foundation, Wisconsin, USA.


The identification of genes contributing to variation in complex phenotypes requires genetic data of high fidelity. Thus, the identification of pedigree and genotyping errors is a crucial prerequisite to the analysis of data from a genome scan for disease genes. The problem has been given little attention in most gene hunting papers; the focus has often been on eliminating mendelian inconsistencies in order that the analysis may proceed, rather than on achieving the best possible data. Though a number of computer programs are available to assist in the identification of genotyping and pedigree errors, the process is still not completely automated. While the Collaborative Study on the Genetics of Alcoholism (COGA) data set for GAW11 is completely compatible with Mendel's rules, there are still some errors present. We inspected the COGA data for the presence of additional errors, and identified five possible pedigree errors.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center