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Eur J Pharmacol. 1999 Nov 3;383(3):R1-2.

Lack of morphine-induced dopamine release in the nucleus accumbens of cannabinoid CB(1) receptor knockout mice.

Author information

1
Department of Neuroscience, <<B.B. Brodie>> University of Cagliari, 09124, Cagliari, Italy.

Abstract

Morphine (10 and 20 mg/kg, s.c.) does not modify dopamine release in the nucleus accumbens of cannabinoid CB(1) knock-out mice under conditions where it dose-dependently stimulates the release of dopamine in the corresponding wild-type mice. These results demonstrate that cannabinoid CB(1) receptors, regulate mesolimbic dopaminergic transmission in brain areas known to be involved in the reinforcing effects of morphine.

PMID:
10594337
DOI:
10.1016/s0014-2999(99)00656-1
[Indexed for MEDLINE]

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