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Cells Tissues Organs. 1999;165(3-4):144-52.

Oct-4: lessons of totipotency from embryonic stem cells.

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  • 1EMBL, Gene Expression Programme, Heidelberg, Germany.

Abstract

The Oct-4 transcription factor is expressed in embryonic stem cells and germ cells of the mouse embryo. Cells that are driven into embryonic and extraembryonic somatic differentiation lose Oct-4 expression. Oct-4 is crucial for the maintenance of the totipotency of embryonic cells at early developmental stages as demonstrated recently by homologous recombination. Since during embryogenesis Oct-4 is restricted to germ cells, it is possible that it plays a key role for the germline lineage by preventing differentiation of these cells during gastrulation. Thus, Oct-4 appears to be a key regulator of totipotency during the life cycle of mammals.

Copyright 1999 S. Karger AG, Basel

PMID:
10592386
DOI:
16694
[PubMed - indexed for MEDLINE]
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