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Curr Opin Neurol. 1999 Oct;12(5):527-33.

Inclusion body myositis.

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Department of Pathology, Göteborg Neuromuscular Center, Sahlgrenska University Hospital, Sweden.


Sporadic inclusion body myositis is a severely disabling muscle disease that mainly affects elderly individuals. The typical distribution of muscle weakness, poor response to immunosuppressive treatment, pathological accumulation of various proteins in vacuolated muscle fibres, inflammatory reaction and mitochondrial changes have all been subjects of recent research that has led to better understanding of the pathogenic events that leads to muscle degeneration and weakness.

[Indexed for MEDLINE]

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