Send to

Choose Destination
See comment in PubMed Commons below
Ann Neurol. 1999 Dec;46(6):925-8.

Leukoencephalopathy associated with a disturbance in the metabolism of polyols.

Author information

  • 1Department of Child Neurology, Free University Hospital, Amsterdam, The Netherlands.


In vivo proton magnetic resonance spectroscopy of the brain demonstrated highly elevated levels of arabitol and ribitol in a 14-year-old boy with a white matter disorder and neuropathy of unknown origin. These polyols also were shown to be elevated in body fluids, suggesting an inborn error in polyol metabolism. The strong plasma/ cerebrospinal fluid/brain gradient, with concentrations increasing in that order, suggests a primary neurometabolic disorder. Thus far, a basic enzyme defect has not been identified.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center