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Vet Immunol Immunopathol. 1999 Nov 30;71(3-4):257-62.

Changes in macrophage and lymphocyte subpopulations of lymphoid tissues from pigs infected with the porcine reproductive and respiratory syndrome virus (PRRSV).

Author information

1
Department of Pathology, National Institute of Animal Health, Tsukuba, Ibaraki, Japan. kawaken@niah.affrc.go.jp

Abstract

We used an immunohistochemical method to investigate changes in macrophage and lymphocyte subpopulations in various lymphoid tissues of pigs in the acute phase of porcine reproductive and respiratory syndrome virus (PRRSV) infection. The numbers of CD8+ cells and B-cells varied among lymphoid tissues after PRRSV infection. In the infected pigs, numbers of CD8+ cells increased in systemic lymphoid tissues whereas numbers of B-cells increased in mucosa-associated lymphoid tissues. There was no difference in the distribution of virus-infected cells and macrophages between lymphoid tissues of the infected pigs. These changes may be associated with the establishment of virus persistence or the emergence of concurrent infection in mucosal organs.

PMID:
10587305
DOI:
10.1016/s0165-2427(99)00102-6
[Indexed for MEDLINE]

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