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Nature. 1999 Nov 25;402(6760):373-6.

Active site-directed protein regulation.

Author information

1
St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia. b.kobe@medicine.unimelb.edu.au

Abstract

Regulation of protein function is vital for the control of cellular processes. Proteins are often regulated by allosteric mechanisms, in which effectors bind to regulatory sites distinct from the active sites and alter protein function. Intrasteric regulation, directed at the active site and thus the counterpart of allosteric control, is now emerging as an important regulatory mechanism.

PMID:
10586874
DOI:
10.1038/46478
[Indexed for MEDLINE]

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