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Microbes Infect. 1999 Dec;1(14):1153-7.

Participation of group 2 CD1 molecules in the control of murine tuberculosis.

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Department of Immunology, University of Ulm, Germany.


Besides the classical major histocompatibility complex (MHC) class I and MHC class II molecules, human CD1 molecules have been shown to present mycobacterial antigens in vitro. In this study, in vivo treatment of mice with anti-CD1 monoclonal antibodies resulted in exacerbated tuberculosis at very early time points. In CD1-modulated mice, Mycobacterium tuberculosis-specific production of the type 1 cytokines, IL-12, TNF, and IFN-gamma as well as of TGF beta was reduced. These findings suggest an antigen-presenting role of CD1 molecules in tuberculosis.

[Indexed for MEDLINE]

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