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Exp Cell Res. 1999 Nov 25;253(1):230-8.

Bioactive lysophospholipids and their G protein-coupled receptors.

Author information

1
Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands. wmoolen@nki.nl

Abstract

Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are serum-borne lysophospholipids that signal through their cognate G protein-coupled receptors to evoke a great variety of responses in numerous cell types. In addition to stimulating cell proliferation and survival, LPA and S1P induce profound cytoskeletal changes through Rho-mediated signaling pathways, leading to such diverse responses as cell rounding, neurite retraction, and modulation of tumor cell invasiveness (transcellular migration). A major recent advance is the identification of a subfamily of heptahelical receptors for LPA and S1P.

PMID:
10579925
DOI:
10.1006/excr.1999.4702
[Indexed for MEDLINE]

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