Format

Send to

Choose Destination
Exp Cell Res. 1999 Nov 25;253(1):180-5.

AP-1: one switch for many signals.

Author information

1
Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, 37232, USA. ronald.m.wisdom@venderbilt.edu

Abstract

The transcription factor AP-1 is activated in response to an incredible array of stimuli, including mitogenic growth factors, inflammatory cytokines, growth factors of the TGF-beta family, UV and ionizing irradiation, cellular stress, antigen binding, and neoplastic transformation. In this review, I discuss genetic evidence that supports a role for AP-1 in the cellular response to some of these stimuli and describe biochemical properties that might explain the ability of this transcription factor to activate different sets of genes in response to different stimuli.

PMID:
10579922
DOI:
10.1006/excr.1999.4685
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center