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Exp Cell Res. 1999 Nov 25;253(1):63-77.

Function of the c-Myc oncogenic transcription factor.

Author information

1
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA. cvdang@welch.jhu.edu

Abstract

The c-myc gene and the expression of the c-Myc protein are frequently altered in human cancers. The c-myc gene encodes the transcription factor c-Myc, which heterodimerizes with a partner protein, termed Max, to regulate gene expression. Max also heterodimerizes with the Mad family of proteins to repress transcription, antagonize c-Myc, and promote cellular differentiation. The constitutive activation of c-myc expression is key to the genesis of many cancers, and hence the understanding of c-Myc function depends on our understanding of its target genes. In this review, we attempt to place the putative target genes of c-Myc in the context of c-Myc-mediated phenotypes. From this perspective, c-Myc emerges as an oncogenic transcription factor that integrates the cell cycle machinery with cell adhesion, cellular metabolism, and the apoptotic pathways.

PMID:
10579912
DOI:
10.1006/excr.1999.4686
[Indexed for MEDLINE]

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