Format

Send to

Choose Destination
Trends Cardiovasc Med. 1999 Apr-May;9(3-4):63-9.

Gap junction communication and the modulation of cardiac neural crest cells.

Author information

1
Biology Department, University of Pennsylvania, Philadelphia 19104, USA.

Abstract

The analyses of transgenic and knockout mice with perturbations in alpha 1 connexin (Cx43) function have revealed an important role for gap junctions in cardiac development. This likely involves the modulation of cardiac crest migration and function. Studies carried out with these mouse models suggest that clinically there may be a novel category of cardiac defects involving crest perturbations that do not include outflow septation defects, but rather involve more subtle defects in the pulmonary outflow tract.

PMID:
10578519
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center