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Ann Intern Med. 1999 Nov 2;131(9):668-72.

Reversal of iron deficiency anemia after Helicobacter pylori eradication in patients with asymptomatic gastritis.

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1
University La Sapienza, Rome, Italy.

Abstract

BACKGROUND:

Iron deficiency anemia is the most common form of anemia worldwide. Recent studies have suggested an association between Helicobacter pylori infection and iron deficiency.

OBJECTIVE:

To investigate the effects of eradicating H. pylori with combination antibiotic therapy on iron deficiency anemia in patients with H. pylori-associated gastritis.

DESIGN:

Case series.

SETTING:

University hospital.

PATIENTS:

30 patients with a long history of iron deficiency anemia in whom H. pylori-associated gastritis was the only pathologic gastrointestinal finding detected.

INTERVENTION:

Eradication therapy with two antibiotics and discontinuation of iron replacement therapy.

MEASUREMENTS:

Complete blood count, ferritin levels, and gastroscopy with biopsy to evaluate H. pylori status.

RESULTS:

At 6 months, 75% of patients had recovered from anemia (P<0.001), ferritin values increased from 5.7+/-0.7 microg/L to 24.5+/-5.2 microg/L (95% CI, 8.85 to 29.97). After 12 months, 91.7% of patients had recovered from anemia.

CONCLUSIONS:

Cure of H. pylori infection is associated with reversal of iron dependence and recovery from iron deficiency anemia.

PMID:
10577329
[Indexed for MEDLINE]
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