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Psychol Med. 1999 Sep;29(5):1151-9.

The prevalence of Gilles de la Tourette syndrome in children and adolescents with autism: a large scale study.

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Department of Experimental Psychology and Psychiatry, University of Cambridge.



An earlier small-scale study of children with autism revealed that 8.1% of such patients were co-morbid for Gilles de la Tourette syndrome (GTS). The present study is a large scale test of whether this result replicates.


Four hundred and forty-seven pupils from nine schools for children and adolescents with autism were screened for the presence of motor and vocal tics.


Subsequent family interviews confirmed the co-morbid diagnosis of definite GTS in 19 children, giving a prevalence rate of 4.3%. A further 10 children were diagnosed with probable GTS (2.2%).


These results indicate that the rate of GTS in autism exceeds that expected by chance, and the combined rate (6.5%) is similar to the rates found in the smaller-scale study. Methodological considerations and alternative explanations for an increased prevalence are discussed.

[Indexed for MEDLINE]

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