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Curr Biol. 1999 Nov 18;9(22):R851-3.

Natural killer cells: stress out, turn on, tune in.

Author information

1
Department of Molecular and Cell Biology, Cancer Research Laboratory, 485 Life Sciences Addition, University of California at Berkeley, Berkeley, 94720-3200, USA.

Abstract

Natural killer cells attack tumor cells, infected cells and some normal cells, but the basis of their specificity is not completely understood. Recent studies indicate that epithelial tumor cells upregulate a stress-induced MHC class-I-like protein termed MICA, triggering NK cells via a recently described receptor called NKG2D.

PMID:
10574749
[Indexed for MEDLINE]
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