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Curr Biol. 1999 Nov 18;9(22):R851-3.

Natural killer cells: stress out, turn on, tune in.

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Department of Molecular and Cell Biology, Cancer Research Laboratory, 485 Life Sciences Addition, University of California at Berkeley, Berkeley, 94720-3200, USA.


Natural killer cells attack tumor cells, infected cells and some normal cells, but the basis of their specificity is not completely understood. Recent studies indicate that epithelial tumor cells upregulate a stress-induced MHC class-I-like protein termed MICA, triggering NK cells via a recently described receptor called NKG2D.

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