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J Pediatr Orthop. 1999 Nov-Dec;19(6):705-9.

Reduction in osteomyelitis and septic arthritis related to Haemophilus influenzae type B vaccination.

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Division of Orthopaedics, Children's Hospital of Eastern Ontario, and University of Ottawa, Canada.


This retrospective cohort study compares organisms responsible for septic arthritis and osteomyelitis before and after Haemophilus influenzae type b vaccination. Before vaccination, Haemophilus influenzae type b was responsible for 5% of culture positive osteomyelitis and 41% of culture positive septic arthritis. Since the administration of the conjugated vaccine PRP-T began in 1992, no case of osteomyelitis or septic arthritis has been caused by Haemophilus influenzae type b (p < 0.005, t test). Vaccination has succeeded in eliminating Haemophilus influenzae type b as an infective agent in hematogenous septic arthritis and osteomyelitis. Current empirical antibiotic therapy for hematogenous septic arthritis and osteomyelitis need only cover gram-positive agents in vaccinated infants and children of all age groups.

[Indexed for MEDLINE]

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