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J Pediatr Orthop. 1999 Nov-Dec;19(6):705-9.

Reduction in osteomyelitis and septic arthritis related to Haemophilus influenzae type B vaccination.

Author information

1
Division of Orthopaedics, Children's Hospital of Eastern Ontario, and University of Ottawa, Canada. andrew.howard@ibm.net

Abstract

This retrospective cohort study compares organisms responsible for septic arthritis and osteomyelitis before and after Haemophilus influenzae type b vaccination. Before vaccination, Haemophilus influenzae type b was responsible for 5% of culture positive osteomyelitis and 41% of culture positive septic arthritis. Since the administration of the conjugated vaccine PRP-T began in 1992, no case of osteomyelitis or septic arthritis has been caused by Haemophilus influenzae type b (p < 0.005, t test). Vaccination has succeeded in eliminating Haemophilus influenzae type b as an infective agent in hematogenous septic arthritis and osteomyelitis. Current empirical antibiotic therapy for hematogenous septic arthritis and osteomyelitis need only cover gram-positive agents in vaccinated infants and children of all age groups.

PMID:
10573336
[Indexed for MEDLINE]

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