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Microbes Infect. 1999 Nov;1(13):1121-7.

Pathogenesis of Mycobacterium avium subspecies paratuberculosis infections in ruminants: still more questions than answers.

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Institut für Mikrobiologie und Tierseuchen, Tierärztliche Hochschule, Hannover, Germany.


Mycobacterium avium subspecies paratuberculosis is the etiologic agent of paratuberculosis (Johnes disease), a chronic enteritis in ruminants, which is one of the most widespread bacterial diseases of domestic animals, causing enormous economic losses worldwide. Though the disease was first described more than a century ago, the biology of the infecting organism and the mechanisms of its interactions with the host still remain a mystery. In this review, recent advances made on pathogenesis of paratuberculosis are summarized and future challenges are discussed.

[Indexed for MEDLINE]

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