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Bioorg Med Chem Lett. 1999 Oct 18;9(20):3031-4.

Quinolizidinyl derivatives of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one as ligands for muscarinic receptors.

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1
Dipartimento di Scienze Farmaceutiche - Università di Genova, Italy.

Abstract

Quinolizidinyl derivatives of the tricyclic systems characterizing pirenzepine and nuvenzepine, were prepared and tested as ligands for muscarinic M1, M2 and M3 receptors; 5,11-dihydro-11-[(S-lupinyl)-thioacetyl]-6H-pyrido[2,3-b][1, 4]benzodiazepin-6-one exhibited IC50 = 10 nM for M1 and 760 nM for both M2 and M3 subtypes. During the synthesis some interesting side compounds were isolated and characterized.

PMID:
10571170
DOI:
10.1016/s0960-894x(99)00528-4
[Indexed for MEDLINE]

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