New pyrrole derivatives as antimycobacterial agents analogs of BM212

Bioorg Med Chem Lett. 1999 Oct 18;9(20):2983-8. doi: 10.1016/s0960-894x(99)00510-7.

Abstract

During the course of our investigations in the field of azole antimicrobial agents, we have identified BM212 a pyrrole derivative with good in vitro activity against mycobacteria and candidae. These findings prompted us to prepare new pyrrole derivatives 2-6 in the hope of increasing the activity. The microbiological data showed interesting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / chemistry
  • Antitubercular Agents / pharmacology*
  • Microbial Sensitivity Tests
  • Mycobacterium / drug effects
  • Piperazines / chemistry
  • Piperazines / pharmacology*
  • Pyrroles / chemistry
  • Pyrroles / pharmacology*

Substances

  • Antitubercular Agents
  • Piperazines
  • Pyrroles
  • BM 212