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Bioorg Med Chem Lett. 1999 Oct 18;9(20):2959-62.

Inhibition of E. coli growth by fullerene derivatives and inhibition mechanism.

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  • 1Kyoritsu College of Pharmacy, Tokyo, Japan.

Abstract

Cationic ammonium fullerene derivatives (C60-bis(N, N-dimethylpyrrolidinium iodide) and C60-bis(N-methylpiperazinium iodide)) suppressed E. coli growth, whereas an anionic derivative (C60-dimalonic acid) did not. Both cationic derivatives inhibited E. coli dioxygen consumption. Inhibition of energy metabolism is concluded to be a mechanism of the growth inhibition effect of fullerene derivatives.

PMID:
10571155
[PubMed - indexed for MEDLINE]
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