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Bioorg Med Chem Lett. 1999 Oct 18;9(20):2909-14.

3-Acyloxy-2-phenalkylpropyl amides and esters of homovanillic acid as novel vanilloid receptor agonists.

Author information

1
Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Korea.

Abstract

A series of 3-acyloxy-2-phenalkylpropyl amides and esters of homovanillic acid were designed and synthesized as vanilloid receptor agonists containing the three principal pharmacophores of resiniferatoxin. Amide analogues 23, 5 and 11 were found to be potent agonists in vanilloid receptor assay both for ligand binding and for activation.

PMID:
10571146
DOI:
10.1016/s0960-894x(99)00513-2
[Indexed for MEDLINE]

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