Format

Send to

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 1999 Oct 22;460(1):57-60.

Activation of Ras by phorbol esters in cardiac myocytes. Role of guanine nucleotide exchange factors.

Author information

1
Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City 84112-5550, USA.

Abstract

The relationship between protein kinase C (PKC) activation and Ras function was investigated in cardiac cells. Ras function was required for ERK activation by phorbol esters in cardiac myocytes, but not in cardiac fibroblasts. Accordingly, treatment with phorbol esters resulted in GTP loading of Ras in cardiac myocytes, but not fibroblasts. Ras activation by phorbol esters was abolished by a PKC specific inhibitor, but was insensitive to tyrosine kinase inhibitors. Ras activation was mediated by stimulation of guanine nucleotide exchange. These results suggest the existence of a novel pathway for Ras activation, specific to cardiac myocytes, with implications for myocardial hypertrophy.

PMID:
10571061
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center