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FEBS Lett. 1999 Sep 24;458(3):363-9.

SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus.

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Division of Protein Metabolism, Institute for Protein Research, Osaka University, Suita, Japan.


To elucidate the mechanism of the circadian rhythm, genes differentially expressed during subjective day and night in the rat suprachiasmatic nucleus (SCN), a circadian oscillator in mammals, were surveyed by a differential display method. We isolated a novel gene, scop (SCN circadian oscillatory protein), that was expressed in a circadian manner in the SCN. SCOP protein is predominantly expressed in the brain and has domains including a pleckstrin homology domain, leucine-rich repeats, a protein phosphatase 2C-like domain and a glutamine-rich region. The structural feature of SCOP protein suggests its role in the intracellular signaling in the SCN.

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