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FEBS Lett. 1999 Sep 24;458(3):363-9.

SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus.

Author information

1
Division of Protein Metabolism, Institute for Protein Research, Osaka University, Suita, Japan. ashimkim@mail.ecc.u-tokyo.ac.jp

Abstract

To elucidate the mechanism of the circadian rhythm, genes differentially expressed during subjective day and night in the rat suprachiasmatic nucleus (SCN), a circadian oscillator in mammals, were surveyed by a differential display method. We isolated a novel gene, scop (SCN circadian oscillatory protein), that was expressed in a circadian manner in the SCN. SCOP protein is predominantly expressed in the brain and has domains including a pleckstrin homology domain, leucine-rich repeats, a protein phosphatase 2C-like domain and a glutamine-rich region. The structural feature of SCOP protein suggests its role in the intracellular signaling in the SCN.

PMID:
10570941
[Indexed for MEDLINE]
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