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Zh Vyssh Nerv Deiat Im I P Pavlova. 1999 Sep-Oct;49(5):780-8.

[Regulation of the mouse aggressive behavior (pharmacologic analysis of the GABAergic mechanism)].

[Article in Russian]

Author information

1
Valdman Institute of Pharmacology, Pavolv State Medical University, St.-Petersburg.

Abstract

Ethological procedures were used to study the effects of GABA-positive drugs on aggression in male albino mice kept in isolation (opponent test). The results revealed several variants of antiaggressive effects of the tested GAB Aergic drugs: 1) antiaggressive, re-socializing of GABAA agonists muscimol (0.125 and 0.5 mg/kg) and THIP (2.0 mg/kg), and GABAB agonist baclofen (2.5-10 mg/kg); 2) antiaggressive, sedative of GABAB agonists baclofen (12.5 mg/kg), phenibut (50-100 mg/kg), and inhibitor of GABA transamininase sodium valproate (100 mg/kg); 3) antiaggressive, anxiogenic for muscimol (1 mg/kg), THIP (5 mg/kg), and sodium valproate (25-50 mg/kg).

PMID:
10570533
[Indexed for MEDLINE]

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