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Biochim Biophys Acta. 1999 Nov 23;1441(2-3):255-67.

Mammalian phosphoinositide-specific phospholipase C.

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Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, UK.


Mammalian phosphoinositide-specific phospholipases C (PI-PLCs) are involved in most receptor-mediated signal transduction pathways. The mammalian isozymes employ a modular arrangement of domains to achieve a regulated production of two key second messengers. The roles of the PH, EF hand, C2, SH2 and SH3 modules in regulation of these enzymes and in interactions with membranes and other proteins is becoming apparent from recent structural and functional studies.

[Indexed for MEDLINE]

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