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Ophthalmologica. 1999;213(6):350-4.

Evaluation of the analgesic effect of 0.1% indomethacin solution on corneal abrasions.

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  • 1Department of Neuroscience and Vision, Section of Ophthalmology R, University of Genoa, Italy.



The authors wished to verify the analgesic action of 0.1% indomethacin in a water-based solution on patients affected by traumatic corneal abrasions.


347 patients affected by traumatic corneal abrasions, having been randomly divided into 2 groups on the basis of the administration of indomethacin, were evaluated at 30 min, 12 h and 24 h after the initial treatment of the abrasion. The level of pain experienced was evaluated on a verbal pain scale and the healing time was evaluated relative to the dimension of the abrasion.


The pain level was initially overwhelming for both groups: p = 0.737; at successive check-ups it was possible to verify a reduction of the symptomatology, with a more pronounced decrease in pain in the group treated with indomethacin (p < 0.0001), which also demonstrated a lower sensitivity to pain in the case of larger lesions (p < 0.0001). There was no difference in the healing time between groups, and the reduction of pain is not correlated with corneal anesthesia and healing time.


Our study highlighted the efficacy of indomethacin as a pain reducer for acute corneal pathology and suggested that the medication may act on the corneal nociceptors in a qualitative way.

[PubMed - indexed for MEDLINE]
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