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Science. 1999 Nov 19;286(5444):1561-5.

Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa.

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Department of Medicine, University of Washington, Seattle, WA 98195, USA.


Cystic fibrosis (CF) patients develop chronic airway infections with Pseudomonas aeruginosa (PA). Pseudomonas aeruginosa synthesized lipopolysaccharide (LPS) with a variety of penta- and hexa-acylated lipid A structures under different environmental conditions. CF patient PA synthesized LPS with specific lipid A structures indicating unique recognition of the CF airway environment. CF-specific lipid A forms containing palmitate and aminoarabinose were associated with resistance to cationic antimicrobial peptides and increased inflammatory responses, indicating that they are likely to be involved in airway disease.

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