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Biochem J. 1999 Dec 1;344 Pt 2:293-6.

Amyloid-beta binds catalase with high affinity and inhibits hydrogen peroxide breakdown.

Author information

1
Department of Molecular Pathology, Royal Free and University College Medical School, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, U.K. nmilton@rfhsm.ac.uk

Abstract

Amyloid-beta (Abeta) specifically bound purified catalase with high affinity and inhibited catalase breakdown of H(2)O(2). The Abeta-induced catalase inhibition involved formation of the inactive catalase Compound II and was reversible. Catalase<-->Abeta interactions provide rapid functional assays for the cytotoxic domain of Abeta and suggest a mechanism for some of the observed actions of Abeta plus catalase in vitro.

PMID:
10567208
PMCID:
PMC1220643
[Indexed for MEDLINE]
Free PMC Article
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