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Curr Opin Clin Nutr Metab Care. 1998 Jul;1(4):347-54.

Vitamin D and regulation of gene expression.

Author information

1
Laboratory for Experimental Medicine and Endocrinology, Faculty of Medicine, Gasthuisberg, Katholieke Universiteit Leuven, Belgium.

Abstract

The function of 1,25-dihydroxyvitamin D3, the biologically active form of vitamin D, extends from bone and mineral homeostasis to the control of cell growth and differentiation in a variety of tissues. Most of these actions are mediated by activation of the nuclear vitamin D receptor, which regulates the transcription of vitamin D target genes. Considerable progress has been made in the understanding of vitamin D receptor function (especially regarding its interaction with coactivators), as well as in the identification of novel vitamin D responsive genes related to cell growth, differentiation and cytokine production.

PMID:
10565372
[Indexed for MEDLINE]

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