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Nat Cell Biol. 1999 Oct;1(6):E163-7.

Determinants of molecular motor directionality.

Author information

1
Department of Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA. endow@abacus.mc.duke.edu

Abstract

Work over the past two years has led to a breakthrough in our understanding of the molecular basis of the directionality of the kinesin motor proteins. This breakthrough has come first from the reversal of directionality of the kinesin-related motor Ncd, followed closely by the reversal of kinesin's directionality and the finding that the Ncd 'neck' can convert Ncd or kinesin, which are intrinsically plus-end-directed microtubule motors, into a minus-end motor. These findings raise several outstanding questions, foremost, how does the neck function in motor directionality?

PMID:
10559980
DOI:
10.1038/14113
[Indexed for MEDLINE]

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