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Nat Cell Biol. 1999 Aug;1(4):234-41.

Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase.

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1
Department of Molecular and Cell Biology, University of California, Berkeley 94720-3202, USA.

Abstract

In metazoans, certain calmodulin-related calcium-binding proteins (recoverins, neurocalcins and frequenins) are found at highest levels in excitable cells, but their physiological roles are largely uncharacterized. Here we show that Saccharomyces cerevisiae contains a frequenin homologue, Frq1, and that its target is Pik1, a phosphatidylinositol-4-OH kinase. Frq1 binds to a conserved sequence motif in Pik1 outside Pik1's catalytic domain and stimulates its activity in vitro. N-myristoylated Frq1 may also assist in Pik1 localization.

PMID:
10559922
DOI:
10.1038/12058
[Indexed for MEDLINE]
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